Day 2 :
Keynote Forum
Alicja Jozkowicz
Jagiellonian University, Poland
Keynote: Nrf2 and Keap1: A quintessential duet in endothelial cells
Time : 09:00-09:30
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Abstract:
Keynote Forum
Sekib Sokolovic
Sarajevo University, Bosnia and Herzegovina
Keynote: Cigarette smokers and arterial stiffness
Time : 09:30-10:00
Biography:
Abstract:
Introduction: The correlation between the arterial stiffness and tobacco users has been verified in a clinical study. Increased arterial stiffness contributes to increased vascular calcifications and atherosclerotic disease and all cardiovascular mortality. Cigarette smokers contribute to 6 million deaths per year globally. Measurement of the arterial stiffness has been recommended in the ESC/ESH guidelines for the arterial hypertension. Material & Method: In order to evaluate the arterial stiffness, the measurement of aortic pulse wave velocity, (APWV), augmentation index (AI), stroke volume, (SV), the reflection gradient (RC) was performed using Agedio Arteriograph. The estimation of cardiovascular risk factors was performed in all examined patients and two groups were formed. One group included smokers and the other one non-smoker healthy subjects. The open outpatient controlled prospective study has been designed. The cardiovascular others risk factors were evaluated in all. Results: Preliminary results obtained have shown the significant increase in APWV, augmentation index and reflection index in smokers group compared to normal arterial stiffness values in non-smokers. Conclusion: These preliminary results have shown that arterial stiffness has been significantly increased in a smoker group whereas the average vascular age has been increased. This finding is additional evidence for the cigarette smoking as risk factor for early vascular pathophysiological changes. The measurements of these parameters are necessary for the cardiovascular risk disease prevention.
Keynote Forum
Marco Piciche
San Bortolo Hospital, Italy
Keynote: Current therapies for refractory angina and potential effects of internal mammary artery occlusion
Time : 10:00-10:30
Biography:
Abstract:
No one knows the true incidence of refractory angina, but it is generally agreed that there are thousands new cases annually. The incidence will presumably increase with the increase of average age. Patients suffering from refractory angina are known as no-option, because they are not amenable to coronary artery bypass grafting or percutaneous coronary interventions. The main reason to be unamenable to conventional revascularization techniques is a diffuse coronary disease, and secondarily comorbidities. Several alternative methods have been advocated, such as stem cell therapy, external counter-pulsation, laser transmyocardial revascularization sympathectomy, partial occlusion of the coronary sinus, shock wave myocardial revascularization. The internal mammary artery (IMAs) has the potential for developing collateral branches under some circumstances. This was the basis for an old operation performed in the 1940s, i.e. the tunnellization of the IMAs in to the left ventricle free wall.
Keynote Forum
Roland Hetzer
Cardio Centrum Berlin, Germany
Keynote: Surgical treatment in heart failure
Keynote Forum
Lale Hakami
University of Munich, Germany
Keynote: Single center results after cardiac transplantation in infants and small children
Time : 10:30-11:05
Biography:
Abstract:
Objectives: Heart transplantation is the last surgical option for infants and young children with congenital heart failure after failed conventional repair or palliative procedures. We aim to present our results in a retrospective and descriptive analysis. Methods: 18 heart transplantations on children (nine female, nine male) were performed from 1988 to 2015. The range of age was between 0 days and 3 years. Indications for a transplantation were hypoplastic left heart syndrome (n=14), non-compactionsyndrome (n=2), Bland-White-Garland-syndrome (n=1) and transposition of the great arteries (n=1). 14 children (78%) had had a previous cardiac surgery. Four patients (22%) required mechanical circulatory support for bridging: ECMO (n=2; 11%), or LVAD and ECMO (n=2; 11%). 15 (83%) underwent a biatrial method, three (17%) a bicaval one. Results: The median waiting time after listing was 68 days (min: 0 days, max: 386 days, standard deviation (SD): 102.8 days). The overall survival was 61%, 13 children (72%) survived the first year. Two patients (11%) had a retransplantation. The median time patients spent at intensive care unit was 17 days (min: 1 day; max: 121 days). They were respirated for seven days (min: 1 day; max: 91 days). Perioperative factors we analyzed were: the median myocardial ischemia time was 236 minutes; the median aortic clamp time was 95 minutes and the median time of circulatory arrest was 60 minutes. Three children (17%) got a pericardial effusion. Two patients (11%) suffered each: bleeding, cardiac arrhythmias, diaphragmatic paresis and cerebral complications. Five (28%) got a lymphoproliferative disease. Seven children (39%) got a coronary graft vasculopathy. Two (11%) needed interventional therapy. Three (17%) got a cardiac pace maker. According to our data, six children had a rejection which called for treatment. Conclusion: Heart transplantation is still the best therapeutic option after end-stage heart failure in children. Cumulative results suggest one additional year of life in more than 70% and a survival of more than 20 years are possible. These results were comparable to those of the ISHLT registry in pediatrics.
- Cardiac Neurodevelopment | Case Reports on Cardiac Surgery | Arrhythmias | Heart Failure
Location: Day 2
Chair
Marco Picichè
San Bortolo Hospital, Italy
Session Introduction
Prerana Banerjee
University Hospital Basel, Switzerland
Title: Off-pump aortic valve bypass to treat severe aortic stenosis
Biography:
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Ossama Maadarani
Ahmadi hospital, Kuwait Oil Company, Kuwait
Title: B-Lines on chest ultrasound predicts elevated left ventricular diastolic pressure
Biography:
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Bin Liu
The Second Hospital of Jilin University, China
Title: Comprehensive strategy to deal with chronic total occlusion
Biography:
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- Pediatric Cardiology | Case Reports on Heart Devices | Cardiac Nursing and Healthcare
Location: Day 2
Chair
Ihor Huk
Medical University of Vienna, Austria
Session Introduction
Muhammad Azam Shah
King Fahad Medical City, Saudi Arabia
Title: Left Atrial Appendage (LAA) Closure with Double WATCHMAN Devices; A case report
Biography:
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Christine Brostjan
Medical University of Vienna, Austria
Title: Histone citrullination of neutrophil extracellular traps is a novel biomarker and target to inhibit progression of abdominal aortic aneurysms
Biography:
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Rostislav Belobrov
Tel -Aviv University, Israel
Title: The association between I.V. cannula size and event of thrombophlebitis at intravenous amiodarone administration
Biography:
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Mirela-Anca Stoia
University of Medicine and Pharmacy Cluj-Napoca, Romania
Title: Cardiovascular risk evaluation before vascular surgery- to be practically or to be pragmatic?
Biography:
Mirela Anca Stoia has her expertise in cardiovascular investigation and diagnostics, based on Cardiology, Internal Medicine and European Fellow in Angiology specializations. She is working in an Emergency Clinical University County Hospital and promoting an integrative medicine, she is implicated in evaluation of atherosclerotic patients in order to assesses the screening and the hierarchs of the multisite arterial lesions for an adequate management in patients undergoing non-cardiac, particularly vascular surgery, in the cardiac patients with other comorbidities association care and in the emergencies cardiac assistance. As an Assistant Professor she teaches Cardiology, Echocardiography, Vascular Ultrasonography and Internal Medicine to medicine students and to residents. Her research interests are related to multidisciplinary cardiology, imaging exploration, biomarkers in cardiology. Her algorithm which identified significant coronary and cervical arterial lesion in patient with critical leg ischemia, from a long experience with many investigated patients, is practical, accessible and applicable.
Abstract:
Statement of the Problem: Patients with peripheral artery disease (PAD) have multisite arterial lesions especially in coronary and cervical arteries, often less symptomatic and diagnosed, which increase dramatically the mortality through myocardial infarction and stroke and the duration of hospitalization, especially after vascular surgery. The purpose of this study was to assess the role of an overall cardiac and arterial screening, including non-invasive and invasive investigation, revealing the role of more accessible examinations, in order to estimate the perioperative cardiovascular risk and to define the therapeutic strategy for revascularization. Methodology & Theoretical Orientation: We studied 142 patients with critical leg ischemia (CLI) scheduled for vascular surgery. The history, clinical examination, cardiovascular risk factors (CVRF) profile and systematic ECG examination of these patients looked for suspected atherosclerotic lesions in coronary and cervical arteries beside the symptomatic peripheral arterial territory. In patient presented acute coronary syndrome in the last six months or Eagle score >2, the coronary angiography was performed systematically. In all patients cervical arterial ultrasonography and in selected patients, cervical arterial angiography was performed. Findings: More of 50% of CLI patients had multiple CVRF. We find significant coronary and/or cervical arterial lesions in 44.4% of the investigated subjects. Hemodynamic significant coronary arteries stenosis >70% were diagnosed in 29.6% and hemodynamic significant cervical stenosis >70% or carotid thrombosis were diagnosed in 11.8% of patients with CLI. The clinical and imagistic non-invasive algorithm selecting patients with CLI and significant stenosis in the coronary and/or arterial cervical territories was confirmed through invasive angiography evaluation in 69.1% of cases. Conclusion & Significance: Demonstrating the multisite arterial lesions profile in patients with CLI and with significant stenosis in coronary and/or cervical arteries changes the treatment strategy and management. In these cases, medical therapy should be more intensive and revascularization interventions in coronary and cervical arteries might precede peripheral arterial revascularization procedures.
Jong-Hau Hsu
Kaohsiung Medical University, Taiwan
Title: Regulatory mechanisms and novel pharmacologic targets of ductus arteriosus
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Volodymyr Isaienko
National Medical Academy, Ukraine